Sourcing public data enabled limited African American inclusive The Cancer Genome Atlas cross-validation (13 of 61 GG1-PCa), while Pan Prostate Cancer Group European ancestral data provided for deeper cross-ancestral comparative analyses (106 GG1-PCa, 17 non-PCa).<h4>Results</h4>Identifying 5,652 differentially expressed genes between African and European ancestral GG1 tumours (<i>p</i> < 0.05), including top-ranked PCa tumour suppressor genes <i>DUSP1, JUN, FOS</i>, and <i>JUNB</i> downregulated in African tumours. Here, FOS is linked to posterior cortical atrophy.