UBAC1 and infection: There were 17 hvCRKP (hypervirulent carbapenem-resistant <i>Klebsiella pneumoniae</i>) strains found in our study, which were mainly ST11-KL64 and ST413-1LV-KL112, harboring the <i>bla</i> <sub>KPC-2</sub> gene and <i>bla</i> <sub>NDM-1</sub> gene, respectively.<h4>Conclusion</h4>In South China, highly virulent and MDR CRKP strains show a trend toward epidemic, underscoring the urgent need for ongoing genomic surveillance and stringent infection control measures.