<h4>Objective</h4>To explore the relationship between glucose-6-phosphate dehydrogenase (G6PD) deficiency and the risk of developing systemic lupus erythematosus (SLE).<h4>Methods</h4>A case-control study was conducted including 516 female SLE patients (SLE group) and 491 age-matched healthy females (control group) from August 2023 to August 2024. This evidence concerns the gene G6PD and G6PD deficiency.