CD79A and celiac disease: The model identified 93% of CeD patients with tTG-IgA levels greater than 10 IU/mL.<h4>Conclusion</h4>Linkage between HLA-B8 and DQ2.5 differs significantly among individuals of European, admixed American, and African ancestry, contributing to ancestry-dependent genetic risk for CeD.<h4>Summary</h4>Using data from the <i>All of Us Research Program</i> , we found that HLA-DQ2.5, a key genetic risk factor for celiac disease, is present in European (11.6%), Admixed American (8.1%), and African (8.1%) populations, but its disease penetrance differs significantly by ancestry.