The pharmacologic management of type 2 diabetes mellitus (T2DM) and cardiovascular diseases, including heart failure, has advanced significantly with the introduction of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose co-transporter-2 inhibitors (SGLT2is), therapies that provide substantial cardiovascular and renal benefits. The gene discussed is GLP1R; the disease is heart failure.