The multivariate Cox and RCS regression analysis showed that after adjusting for confounding factors, the AIP level were non-linear associated with risk of all-cause death (HR = 5.427, 95%CI=2.999-9.821, inverted U-shape) and non-recovery of renal function (HR = 2.769, 95% CI = 2.085-3.677, S-shape) in diabetic patients with AKI. The gene discussed is AIP; the disease is acute kidney injury.