In COPD mice, GOG significantly decreased the elevated numbers of neutrophils, total cells, macrophages, and Gr-1<sup>+</sup>/Siglec-F, Gr-1<sup>+</sup>/CD11b<sup>+</sup>, and CD44<sup>high</sup>/CD62L<sup>-</sup> cells. Here, ITGAM is linked to chronic obstructive pulmonary disease.