Furthermore, both CKAB-P1 and C3G attenuated phosphorylation of JAK1 and STAT3.<h4>Conclusions</h4>These findings suggest that anthocyanin-enriched black rice fraction may limit inflammation-driven A549 lung cancer cell aggressiveness through modulation of the cytokine-driven JAK1/STAT3 signaling cascade, indicating its potential relevance as a bioactive dietary component targeting tumor-associated inflammatory signaling. The gene discussed is JAK1; the disease is lung cancer.