<b>Results:</b> Our SMR analysis identified suggestive associations between <i>NLRP6</i> expression (OR = 0.528, 95%CI = 0.291-0.96) and p27Kip1 protein abundance (OR = 0.269, 95%CI = 0.08-0.904) with SLE susceptibility in the discovery cohort, supported by colocalization evidence. The gene discussed is CDKN1B; the disease is systemic lupus erythematosus.