<b>Background:</b> The aim of our study was to evaluate the association of angiopoietin 2 (<i>ANGPT2</i>) rs2442598 and vascular endothelial growth factor A (<i>VEGFA</i>) rs2010963 with diabetic nephropathy (DN) in Slovenian subjects with type 2 diabetes mellitus (T2DM). This evidence concerns the gene ANGPT2 and diabetes mellitus.