The compounds showed negligible inhibition of the cytosolic isoforms <i>h</i>CA I and <i>h</i>CA II, while displaying moderate activity toward the tumor-associated isoforms <i>h</i>CA IX and <i>h</i>CA XII, with Ki values ranging from 12.9 to 41.8 μM. The gene discussed is CA1; the disease is neoplasm.