Pathogenic variants in the <i>PMP22</i> gene can lead to hereditary peripheral demyelinating neuropathies of varying severity, including hereditary neuropathy with liability to pressure palsies (HNPP), Charcot-Marie-Tooth disease types 1A and 1E (CMT1A, CMT1E), Roussy-Lévy syndrome, and Dejerine-Sottas disease (DSS). This evidence concerns the gene PMP22 and Charcot-Marie-Tooth disease type 1A.