<i>IRF1</i>, <i>IRF9</i> and <i>STAT1</i> in lymphoid cells of C1 participated in anti-tumor immune response by impacting target genes <i>CD8A</i>, <i>HLA-A/E</i>, <i>TAP1</i> and <i>PD-1</i>. This evidence concerns the gene IRF1 and neoplasm.