<i>JUN</i>, <i>FOS</i>, <i>STAT3</i>, <i>JUND</i> and <i>NR2F1</i> were up-regulated in clusters C2 and C3, leading to tumor progression and immune evasion by influencing target genes <i>HSPA1A</i>, <i>CXCL9</i> and <i>PDGFR</i>. The gene discussed is JUND; the disease is neoplasm.