Preclinical studies demonstrate that PIC exerts multi-target effects relevant to skin aging and acne, including ROS scavenging, anti-inflammatory activity via NF-κB/MAPK inhibition, suppression of melanogenesis, enhancement of hyaluronic acid and collagen synthesis, and antibacterial action against <i>Cutibacterium acnes</i>. Here, NFKB1 is linked to acne.