Experimental evidence indicates that a high seizure burden can induce cerebral overexpression of P-glycoprotein (P-gp) at the blood-brain barrier, a phenomenon associated with drug-resistant epilepsy under the "transporter hypothesis", but also at the neuronal level, linked to a reduced seizure threshold, increased seizure severity (SS), status epilepticus (SE), and a high spontaneous death (SD) rate. The gene discussed is PGP; the disease is epilepsy.