This case-control study investigated associations between <i>IL6</i> rs1800795, <i>TNF</i> rs1800629, <i>CCL2</i> rs1024611, and <i>VEGFA</i> rs699947 polymorphisms, circulating cytokine levels, clinicopathological characteristics, and autonomic nervous system balance assessed by heart rate variability (HRV) in 73 BC patients and 88 controls. This evidence concerns the gene CCL2 and breast cancer.