MGMT and neoplasm: We aimed to determine whether subcompartment-level radiomic features associate with transcriptomic pathway enrichment scores derived from biologically approximate tumor zones.<h4>Methods</h4>We matched 28 patients (mean age 58.5 years; 13/28 <i>MGMT</i> methylated) across the IvyGAP RNA-seq atlas and the IVYGAP-RADIOMICS datasets.