Recurrent bacterial and viral signals, including <i>Cutibacterium acnes</i>, <i>Escherichia coli</i>, <i>Pseudomonas</i>, <i>Acinetobacter</i>, human papillomavirus, Epstein-Barr virus, and cytomegalovirus, appear to converge on a restricted set of tumor-relevant pathways, including TLR-NF-κB, MAPK, PI3K/AKT/mTOR, cGAS-STING, and p53/pRb disruption. The gene discussed is TP53; the disease is neoplasm.