This study aimed to evaluate whether vitamin D and adiponectin levels differ among pediatric groups defined by their asthma and obesity status, to better characterize the metabolic and inflammatory profile of the obesityasthma phenotype.<h4>Methods</h4>A total of 120 participants aged 6-18 were enrolled and categorized into four groups: Asthma (<i>n</i> = 30), Obesity (<i>n</i> = 30), Asthma + Obesity (<i>n</i> = 30), and Control group (<i>n</i> = 30). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.