A similar difference was observed between the controls and obese asthmatics among children with low vitamin D levels (<i>p</i> = 0.014).<h4>Conclusions</h4>The dominant mechanisms underlying the obesity-asthma phenotype remain unclear; however, our findings indicate a link between adiponectin dysregulation and heightened airway inflammation, as evidenced by increased FeNO levels, though the precise pathways involved are still not well-understood. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.