<b>Objective:</b> To evaluate the diagnostic and prognostic utility of the hemoglobin-albumin-lymphocyte-platelet (HALP) score and several systemic inflammatory indices derived from routine blood parameters-including the systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), pan-immune inflammation value (PIV), and systemic inflammatory response index (SIRI)-for pathogen differentiation and clinical assessment in culture-proven late-onset neonatal sepsis (LOS). Here, ALB is linked to Neonatal sepsis.