<i>LRRK2</i> G2019S mice treated with BK40196 exhibit distinct increases in DA in mesolimbic neurons such as the nucleus accumbens (NAcc), suggesting differential mechanisms of DA neurotransmission in mutant alpha-synuclein and <i>LRRK2</i> models of PD. The gene discussed is LRRK2; the disease is Parkinson disease.