In the age-adjusted Mantel-Haenszel stratified analysis of the HNMT C314T polymorphism, the C allele was identified as a risk factor for PD development in this small cohort, with an OR (95% CI) of 12.0 (0.8-160.4; <i>p</i> = 0.041). This evidence concerns the gene HNMT and Parkinson disease.