A total of 136 patients with clinical suspicion of prostate cancer-defined as elevated prostate-specific antigen (PSA), abnormal digital rectal examination, or PIRADS ≥3 on multiparametric MRI-underwent transperineal MR/US fusion-guided biopsy between January 2023 and October 2024. The gene discussed is KLK3; the disease is Familial prostate cancer.