albicans</i> infection induced ferroptosis in vaginal tissues and macrophages, as manifested by lipid ROS accumulation, Fe<sup>2+</sup> overload, GSH depletion, downregulation of GPX4 and SLC7A11, upregulation of ACSL4, 4-HNE, and MDA, and mitochondrial structural damage. This evidence concerns the gene ACSL4 and infection.