Between the patients with panuveitis and patients with only posterior or anterior uveitis, serum Ang-1 (P < .001), Tie-2 (P < .001), EphrinB2 (P < .001), EphB4 (P = .001), and endocan (P = .002) levels had statistically significant differences. This evidence concerns the gene EPHB4 and panuveitis.