Here, we aimed to test whether immunophenotypes of specific glutathione peroxidase (GPX) family members may have prognostic value in RCC.<h4>Methods</h4>We investigated the relationship between GPX1 and GPX3 immunophenotypes and clinicopathological parameters in 32 surgical specimens of clear cell RCC (ccRCC) with nucleolar grade 1-4 (WHO/ISUP grading). This evidence concerns the gene GPX3 and renal cell carcinoma.