However, we did find statistically significant positive correlations between GPX1 expression and invasion of the renal vein (<i>p</i> = 0.038), perirenal fat (<i>p</i> = 0.043), and peripyelic fat (<i>p</i> = 0.015).<h4>Conclusion</h4>Our data demonstrate that GPX1 and GPX3 immunophenotypes could have a prognostic role for ccRCC, particularly in relation to nucleolar grade. Here, GPX3 is linked to nonpapillary renal cell carcinoma.