SERPINE1 and androgen insensitivity syndrome: The combined model demonstrated excellent calibration (Brier score 0.135), good internal validity (optimism-corrected C-index 0.874), and positive net benefit across a wide threshold probability range (0.15-0.80) on DCA.<h4>Conclusion</h4>Elevated serum MMP-9 and NLR levels were independently associated with poor short-term prognosis in elderly AIS patients, while PAI-1 showed a consistent direction of association and contributed to the overall performance of the combined model.