MLXIPL and diabetic kidney disease: The glucose-responsive transcription factor carbohydrate response element-binding protein (ChREBP; encoded by <i>MLXIPL</i>) regulates glycolytic-lipogenic programs, yet its causal contribution to renal injury is challenging to disentangle in advanced DKD, where bulk kidney transcriptomes reflect tissue remodeling and cellular compositional shifts.<h4>Methods</h4>We integrated two-sample Mendelian randomization (MR), kidney transcriptomic stratification, network analyses, and experimental validation.