Concurrently, CHWD remodeled the omental immune microenvironment by restoring omentin-1 secretion and promoting macrophage phenotype switching, characterized by maintenance of a CD68<sup>+</sup> macrophage population accompanied by suppression of iNOS-mediated cytotoxic effector functions.<h4>Conclusion</h4>CHWD alleviates HFD-induced obesity and metabolic inflammation by coordinately targeting the PTEN/AKT/mTOR axis and reprogramming omental immunity. Here, CD68 is linked to obesity due to melanocortin 4 receptor deficiency.