This study aimed to investigate the therapeutic mechanisms of CHWD in high-fat diet (HFD)-induced obesity model, specifically focusing on insulin signaling and immune microenvironment remodeling in the liver-omentum axis.<h4>Method</h4>C57BL/6J mice were fed a HFD to induce obesity and treated with CHWD. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.