This study investigates whether METTL3 influences the immune microenvironment of renal cell carcinoma (RCC) via m6A-dependent PI3K/AKT pathway activation and explores its translational potential.<h4>Methods</h4>METTL3 expression was assessed in tumor and adjacent tissues from 34 RCC patients using Western blot and immunohistochemistry. The gene discussed is METTL3; the disease is hereditary clear cell renal cell carcinoma.