This study evaluated the predictive value of the aggregate index of systemic inflammation (AISI), the C-reactive protein-albumin-lymphocyte (CALLY) index, and their combined use for PPCs after McKeown esophagectomy following nICT.<h4>Methods</h4>We retrospectively analyzed 412 consecutive ESCC patients who underwent McKeown esophagectomy after nICT between January 2019 and December 2025. Here, ALB is linked to esophageal squamous cell carcinoma.