These genes exhibited high diagnostic accuracy and significant correlations with disease severity and immune cell infiltration.<h4>Conclusions</h4>This study identified six hub genes-ADRB2, WNT5A, S100A9, FAM110C, S100A12, and TUBB6-as potential cross-disease biomarkers for the comorbidity of psoriasis and MAFLD, and these genes are significantly associated with disease severity. This evidence concerns the gene TUBB6 and psoriasis.