DNA methylation (DNAm) of the oxytocin receptor gene (<i>OXTR</i>) has been associated with socioemotional functioning and individual differences in temperament, yet its role in children with neurodevelopmental disabilities (NDs) remains underexplored.<h4>Methods</h4>The present study examined <i>OXTR</i> DNAm across 13 CpG sites within intron 1 in a sample of 24 children with NDs and 24 typically developing (TD) children aged 3-36 months. This evidence concerns the gene OXTR and Neurodevelopmental abnormality.