In addition, higher creatinine levels (<i>p</i> = 0.034), elevated C-reactive protein (CRP) levels (<i>p</i> = 0.01), hypoalbuminemia (<i>p</i> = 0.018), narrower SCA values (<i>p</i> = 0.025), and higher Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores (<i>p</i> = 0.001) were associated with mortality.<h4>Conclusion</h4>Narrower SCA values, advanced age, elevated creatinine and CRP levels, hypoalbuminemia, and higher APACHE-II scores were associated with increased mortality in chronic obstructive pulmonary disease (COPD) patients admitted to the ICU. This evidence concerns the gene CRP and Hypoalbuminemia.