Crucially, key bioinformatic predictions were validated in established <i>in vitro</i> cell models of gout and MetS using quantitative real-time PCR (qPCR) and Western blot analysis.<h4>Results</h4>A total of 261 CODEGs were identified, leading to the selection of 19 hub genes, including JAK1 and CSF1R. The gene discussed is JAK1; the disease is gout.