For rs1048943 (A>G): Carrying the G allele was associated with decreased PCa risk in multiple models: allele model (G vs A: OR = 0.80, 95%CI: 0.71-0.90, P<0.001); homozygous model (GG vs AA: OR = 0.56, 95%CI: 0.42-0.76, P<0.001); dominant model (GA+GG vs AA: OR = 0.72, 95%CI: 0.55-0.94, P = 0.02); recessive model (GG vs GA+AA: OR = 0.78, 95%CI: 0.62-0.99, P = 0.04).<h4>Conclusion</h4>The C allele of CYP1A1 rs4646903 may increase PCa risk under the dominant model. The gene discussed is CYP1A1; the disease is posterior cortical atrophy.