<h4>Objective</h4>To evaluate the associations between C allele of CYP1A1 rs4646903 (T>C) and G allele of CYP1A1 rs1048943 (A>G) polymorphisms and prostate cancer (PCa) susceptibility under different genetic models.<h4>Methods</h4>We systematically searched PubMed, EMBASE, CNKI, and Wanfang databases from inception to December 31, 2024. This evidence concerns the gene CYP1A1 and Familial prostate cancer.