TARDBP and Alzheimer disease: Recent findings suggest increased phosphorylated TDP-43 (pTDP-43) inclusions in astrocytic endfeet in AD and a bidirectional interaction between Aβ and TDP-43, promoting mutual aggregation.<h4>Methods</h4>We analyzed pTDP-43 immunoreactivity (IR) in astrocytic perivascular end-feet, nuclei, and cytosol in hippocampal sections from 3-month-old and 18-month-old App<sup>NL-F/NL-F</sup> mice and 18-month-old wild-type controls using ImageJ.