LGR5 and colitis: Compared with wild-type mice, depleting tetrameric STAT5 in mice significantly increased ISC-mediated intestinal epithelial hyperplasia, TCR gene signatures, crypt TCRγδ<sup>+</sup> T cells with elevated STAT5 tyrosine phosphorylation (pYSTAT5) and IL-17A levels, amplified both Lgr5<sup>hi</sup> and Lgr5<sup>low</sup> ISC proliferation and promoted de novo crypt regeneration with increased TCRγδ<sup>+</sup> cell influx post irradiation or colitis.