TSPO and major depressive disorder: Moreover, lower quality of life was associated with higher DVRs in the hippocampus, amygdala and thalamus (ρ = - 0.83- - 0.70), and depression and anxiety correlated positively with DVRs in the hippocampus and amygdala (ρ = 0.75-0.97).<h4>Conclusions</h4>LC TSPO availability did not differ from HCs in any studied brain area.