These effects were weakened by G15 or GPR30 knockdown; docking supported a stable TXA-GPR30 interaction.<h4>Conclusions</h4>TXA showed clinical anti-wrinkle activity in melasma patients and protected HDFs from D-gal-induced senescence, partly <i>via</i> GPR30-dependent modulation of oxidative stress, SASP/ECM expression, and MAPK signalling. Here, GPER1 is linked to freckles.