The aim of this study was to assess the ability of lipocalin-2, receptor for advanced glycation end products (RAGE), tissue inhibitor of metalloproteinase 1 (TIMP-1), osteopontin, and trefoil factor 3 (TFF-3) in predicting the prognosis of patients with CKD.<h4>Materials and methods</h4>We included patients with CKD as defined by an estimated glomerular filtration rate of <60 mL/min/1.73 m<sup>2</sup> of either sex who were above the age of 18 years. Here, SPP1 is linked to chronic kidney disease.