INS and inherited lipid metabolism disorder: In visceral adipose tissue, increased mRNA Hif1</i> may contribute to adipose tissue hypoxia and impair insulin sensitivity, particularly in males.<h4>Conclusions</h4>Despite having more pronounced dyslipidaemia, ectopic lipid accumulation, and visceral adiposity, prediabetic females have better glucose tolerance and insulin sensitivity markers than prediabetic males.