Immune checkpoint inhibitors, especially when combined with tyrosine kinase inhibitors (TKIs), locoregional therapies, or radiotherapy, are reshaping the management of advanced HCC; however, the optimal way to integrate these modalities, particularly in patients with vascular invasion and low programmed death-ligand 1 (PD-L1) expression, remains uncertain. Here, CD274 is linked to hepatocellular carcinoma.