This study aims to identify gene sets associated with radiotherapy effectiveness and immune infiltration in lung adenocarcinoma (LUAD), construct a prognostic model, and preliminarily evaluate the effectiveness of the key gene TSPAN32 as a predictive diagnostic marker and therapeutic target for LUAD.<h4>Methods</h4>Genomic datasets from The Cancer Genome Atlas (TCGA) were analyzed to develop a 12-gene risk score model. This evidence concerns the gene TSPAN32 and lung adenocarcinoma.