<h4>Purpose</h4>This study aimed to investigate the effect of ginsenoside Rb1 (Gs-Rb1) on endothelial cell (EC) pyroptosis in atherosclerosis (AS).<h4>Method</h4>ApoE<sup>-/-</sup> mice and mouse aortic endothelial cells (MAECs) were used as research subjects. The gene discussed is APOE; the disease is atherosclerosis.