ADA and Anxiety: We also observed significant differential gene expression within the adenosine signaling pathway between the reactive and proactive strains, where reactive zebrafish expressed higher levels of adenosine receptors A1B, A2Ab, A2B, and ada, and lower levels of adenosine receptor A2Aa than proactive zebrafish.<h4>Conclusion</h4>These findings indicate that variation in adenosine signaling between the stress coping styles and sexes may be contributing to differences in anxiety-related behavior.