An in vitro co-culture model involving Echinococcus multilocularis protoscolex-stimulated endothelial progenitor cells (EPCs), JS1 hepatic stellate cells (JS1) and RAW264.7 macrophages was established to evaluate angiogenesis, fibrogenic activity and macrophage polarization.<h4>Results</h4>Integrated bioinformatics and molecular docking analyses revealed CCL2-CCR2 overexpression and high-affinity binding during AE progression. This evidence concerns the gene CCL2 and acrodermatitis enteropathica.