PBMCs from patients with advanced hepatocellular carcinoma (HCC) responding and nonresponding to atezolizumab (anti-PD-L1) and bevacizumab (anti-VEGF) are cocultured with Huh7 and SNU449 HCC cell lines directly grown onto OECTs. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.