Additionally, we systematically reviewed and summarized the reported functional roles and molecular mechanisms of DLEU1 over the past five years.<h4>Results</h4>This meta-analysis, incorporating nine studies with a total of 938 cancer patients, demonstrated that elevated DLEU1 expression was significantly associated with shortened overall survival and adverse clinicopathological features, including lymph node metastasis and advanced TNM stage. The gene discussed is DLEU1; the disease is metastatic malignant neoplasm in the lymph nodes.