Protein-protein interaction (PPI) analysis identified 30 hub nodes, which were further subjected to Gene Ontology and KEGG enrichment analyses.Subsequently, the circRNA/miRNA/mRNA regulatory axis was assessed, followed by validation using qRT-PCR and evaluation through ROC curve analysis.<h4>Results</h4>Four core genes-<i>STAT1</i>, <i>BCL2</i>, <i>TRAF6</i>, and <i>IL1A</i>-were enriched in tuberculosis,JAK-STAT,and NF-κB pathways. This evidence concerns the gene STAT1 and tuberculosis.